Weill Cornell Medicine Events

“Rare and Common variation implicate microglial function in Alzheimer’s disease risk”

Alison Goate, D.Phil., Willard T.C. Johnson Research Professor of Neurogenetics, Director, Ronald M. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai

 

Alzheimer’s disease is a common neurodegenerative disease that has no effective treatment. We are using genetic approaches to determine the underlying mechanisms of disease with the goal of identifying novel therapeutic targets for treatment. Informatic analyses indicate that AD heritability is enriched within epigenetic annotations for active enhancers in myeloid cells. Specifically, the cistrome for the myeloid transcription factor PU.1 is highly enriched for AD risk loci, including APOE and MS4A4A, implicating a specific functional network in AD risk.

Thursday, February 14 at 4:00pm to 5:00pm

Weill Auditorium
1300 York Ave New York, NY 10065

Event Type

Lecture/Seminar, Basic Science Lecture/Seminar

Departments

Brain and Mind Research Institute

Mission

Research

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