Progress in Neuroscience Seminar Series (PINS): Vascular Contributions to Alzheimer’s Disease

Sidney Strickland, PhD, Zachary and Elizabeth M. Fisher Professor, The Rockefeller University

Abstract: 

The fundamental pathology in Alzheimer’s disease (AD) is neuronal dysfunction leading to cognitive impairment. The amyloid-beta peptide (Aβ), derived from amyloid precursor protein, is one driver of AD, but how it leads to neuronal dysfunction is not established. In this talk, I will discuss the complexity of AD and possible cause-and-effect relationships between Aβ and the vascular and hemostatic systems. AD can be considered a multifactorial syndrome with various contributing pathological mechanisms. Therefore, as is routinely done with cancer, it will be important to classify patients with respect to their disease signature so that specific pathologies, including vascular pathways, can be therapeutically targeted.

Citations: 

Strickland S.J Clin Invest. 2018 Feb 1;128(2):556-563. doi: 10.1172/JCI97509. Epub 2018 Feb 1.PMID: 29388925