Nii A. Addy, PhD

Associate Professor of Psychiatry and of Cellular and Molecular Physiology

Co-Director, Minority Organization for Retention & Expansion (MORE) Faculty Mentoring Program

Associate Director of Diversity, Biological Sciences Training Program (BSTP) in Psychiatry

Yale School of Medicine

Abstract: Dr. Addy’s research focuses on the neurobiological processes underlying substance use disorders, mood disorders, and comorbid substance use and mood disorders. Dr. Addy’s team uses multiple methodologies, including behavioral paradigms such as intravenous drug self-administration, acute and chronic stress paradigms, and anxiety and amotivation paradigms, along with integrated pharmacological, in vivo electrochemical, and in vivo optogenetic methods to investigate these mechanisms. Dr. Addy will present his preclinical findings, in collaboration with Dr. Anjali Rajadhyaksha, revealing cholinergic and L-type calcium channel processes in the mesolimbic system that robustly mediate substance use and mood disorder behavioral phenotypes through regulation of dopaminergic activity. Dr. Addy will also describe ongoing work with potential therapeutic compounds, targeting subtype-specific muscarinic receptors and L-type calcium channels. Finally, he will describe upcoming clinical collaborative studies, based on his team’s recent preclinical findings.   

Email veb2012@med.cornell.edu for zoom link