Jie Shen Ph.D., Professor of Neurology, Harvard Medical School
The major research interests of the Shen laboratory focus on elucidation of the pathogenic mechanisms of Alzheimer’s and Parkinson’s diseases. Specifically, a multidisciplinary approach is employed to investigate the molecular and cellular mechanisms underlying pathologic degeneration of specific neuronal populations.
1) Xia et al. Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer’s disease. Neuron 2015, 85: 967-81.
2) Kang et al. An Evolutionarily conserved role of Presenilin in neuronal protection in the aging Drosophila brain. Genetics 2017, 206: 1479-93.
3) Giaime E et al. Age-dependent dopaminergic neurodegeneration and impairment of the autophagy-lysosomal pathway in LRRK-deficient mice. Neuron 2017, 96:796-807.
Thursday, February 20 at 4:00pm to 5:00pm
1300 York Ave New York, NY 10065
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