Weill Cornell Medicine Events

EIPM Seminar Series: Anna S. Tocheva, Ph.D. - "Oncogenic signatures of tumor sensitivity and resistance to IFN-gamma"

We leverage patient-derived 3D organoid models from different cancers, which reproduce the oncogenic programs of human tumors, to reveal cellular and molecular mechanisms underlying tumor-intrinsic sensitivity to IFNg. The talk will address:

  • How intratumoral genetic heterogeneity influences sensitivity to IFNg signaling.
  • How intratumoral genetic heterogeneity influences the expression of IFNg-induced and therapeutically relevant immune checkpoints and soluble mediators. Such insights are key to the development of combination treatments targeting immune checkpoint ligands and tumor-specific vulnerabilities.
  • Given the critical role of IFNg in antitumor immunity, we address how tissue-specific and tumor-intrinsic differences must be considered to identify targetable immunophenotypes and underlying molecular cascades that influence IFNg responsivity and ICB efficacy.

About Dr. Anna S. Tocheva:
My laboratory integrates cellular and molecular immunological assays with high-throughput proteomic and genomic approaches to study the signaling pathways triggered by immune checkpoints in human T cells. In parallel, we develop scalable approaches that incorporate cancer patient-derived organoids with reconstituted immune cells allowing us to translate these fundamental immunobiology discoveries into functional pre-clinical immunoassays to identify mono- and combination immunotherapies that augment anti-tumor T cell responses.

— Anna S. Tocheva, Ph.D.
Assistant Professor
Department of Genetics and Genomic Sciences
Icahn School of Medicine at Mount Sinai

Dial-In Information

Email Victoria Cummings at vjc4001@med.cornell.edu for Zoom information.

Thursday, June 6 at 12:00pm to 1:00pm

Belfer Research Building, BB 302-A
413 East 69th St., New York, NY 10021

Event Type

Lecture/Seminar, Continuing Medical Education (CME), Regularly Scheduled CME Event

Departments

Institute for Precision Medicine

Mission

Education, Research

Website

https://eipm.weill.cornell.edu/news-e...

Hashtag

#EIPM

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Anna S. Tocheva

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