Weill Cornell Medicine Events

“Cholinergic involvement in stress-related behaviors in mice and humans”

Marina R. Picciotto, PhD.

Charles B.G. Murphy Professor in Psychiatry, Professor of Neuroscience and Pharmacology

Yale University School of Medicine

The cholinergic system has been implicated in adaptive and maladaptive behavioral responses to stress. In particular, work in human subjects has shown that acetycholine (ACh) levels are elevated when unipolar and bipolar individuals are actively depressed, and work in our laboratory has shown that ACh signaling in the basolateral amygdala (BLA) is important for unconditioned responses to stress. We have demonstrated that pharmacological or molecular genetic manipulations of ACh signaling through nicotinic ACh receptors (nAChRs) in BLA is sufficient to recapitulate effects of systemic modulation of the nicotinic system on stress-induced behaviors in male and female mice. In our current studies, we have begun to identify the cell types and microcircuits in BLA involved in nAChR-mediated changes in anxiety-like behaviors.

Thursday, April 25 at 4:00pm to 5:00pm


A-950 Auditorium
1300 York Ave New York, NY

Event Type

Lecture/Seminar, Basic Science Lecture/Seminar

Departments

Brain and Mind Research Institute

Mission

Research

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