Weill Cornell Medicine Events

"Bridging the Gap Between Cellular and Mesoscopic Brain Imaging"

Part of the Progress in Neuroscience Seminar (PINS) series

Serge Charpak, M.D., Ph.D.
Inserm Research Director


"I will describe a decade of research on how functional imaging based on blood flow dynamics actually reports neuronal activation. Our approach is based on two-photon microscopy imaging of cellular activity, functional ultrasound imaging of blood volume (fUS) and BOLD fMRI in the rodent brain."


  • Aydin AK, Haselden WD, Goulam Houssen Y, Pouzat C, Rungta RL, Demené C, Tanter M, Drew PJ, Charpak S, Boido D. (2020) Transfer functions linking neural calcium to single voxel functional ultrasound signal, Nat Commun. 11:2954. doi: 10.1038/s41467-020-16774-9.
  • Boido D, Rungta RL, Osmanski BF, Roche M, Tsurugizawa T, Le BD, Ciobanu L, Charpak S (2019) Mesoscopic and microscopic imaging of sensory responses in the same animal. Nat Commun 10:1110. doi: 10.1038/s41467-019-09082-4
  • Rungta RL, Chaigneau E, Osmanski BF, Charpak S (2018) Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia. Neuron 99:362-375. doi: 10.1016/j.neuron.2018.06.012
  • Parpaleix A, Houssen YG, Charpak S (2013) Imaging local neuronal activity by monitoring PO(2) transients in capillaries. Nat Med 19:241-246. doi: 10.1038/nm.3059

Dial-In Information

Contact Sophy Aguilar: sot2002@med.cornell.edu for Zoom details.

Thursday, October 21 at 4:00pm to 5:00pm

Virtual Event
Event Type



Brain and Mind Research Institute



Event Contact

Sophy Aguilar: sot2002@med.cornell.edu

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Serge Charpak

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