The David Smith Workshop is a clinically focused genetics meeting on dysmorphology, syndrome recognition, and rare disease diagnosis, with attention to the developmental and molecular mechanisms that underlie congenital anomalies and syndromic presentations. Through invited talks and case-based discussions, the meeting connects bedside pattern recognition with mechanisms such as disrupted embryologic development, gene regulation, signaling pathways, chromatin biology, dosage sensitivity, mosaicism, and genotype–phenotype correlation. Attendance is limited to individuals with accepted abstracts.