This is the 21^st annual update on HIV infection.  The course is intended for practitioners (primarily physicians but also nurse practitioners, physician assistants, and registered nurses) who care for HIV-infected patients in their practices.  The program will consist of five state-of-the-art thirty minute lectures by experts in the field plus time for questions and answers from the audience.  Lectures will focus on recent advances in the area of HIV (antiretroviral) therapy, cardiovascular disease in people living with HIV, status of the search for an HIV cure and an HIV vaccine and  intersection between the HIV and opioid epidemics.