Helen Bateup, PhD
Associate Professor of Neurobiology
Research in my lab broadly aims to understand the cellular and molecular basis of neuropsychiatric disorders. We have a particular interest in “mTORopathies”, which are developmental brain disorders caused by mutations in the mTOR signaling pathway that lead to epilepsy, intellectual disability, and increased risk for autism spectrum disorder. To elucidate disease mechanisms for these disorders, we use genetically-defined mouse and human cellular models in combination with a variety of techniques spanning molecular profiling to behavioral analysis. Our goal is to generate a mechanistic understanding of how disease-associated mutations affect the cell biology and physiology of specific types of neurons, and how altered neuronal activity impacts circuit function and behavior. In addition, we are investigating the early developmental alterations that may contribute to mTOR-related disorders using genetically engineered and patient-derived human brain organoids.
Kosillo P, Doig NM, Ahmed KM, Agopyan-Miu AHCW, Wong CD, Conyers L, Threlfell S, Magill PJ, and Bateup HS
Nature Communications. November 28, 2019.
Blair JD, Hockemeyer D, and Bateup HS
Nature Medicine. October 24, 2018.
Benthall KN, Ong SL, Bateup HS
Cell Reports. June 12, 2018.
Email email@example.com for zoom link
Thursday, February 25 at 4:00pm to 5:00pmVirtual Event