Weill Cornell Medicine Events

Inhibition, Homeostasis and Autism in the Cerebral Cortex

The sensory cortex represents a powerful model for studying the function and plasticity of cortical circuits. Inhibitory circuits exhibit robust experience-dependent plasticity with mechanisms and functional roles that remain incompletely understood. Dan Feldman, Ph.D., and his team have focused on ParValbumin (PV) interneuron circuits. In the whisker somatosensory cortex (S1), PV circuits are weakened by whisker deprivation, altering Excitation-Inhibition (E-I) ratio in a manner that stabilizes synaptic potentials. This plasticity appears to act as a rapid homeostat to stabilize cortical activity in response to transient changes in sensory drive. This homeostatic perspective led the team to study the E-I ratio hypothesis for autism, in which reduced inhibition and elevated E-I ratio are proposed to drive circuit hyperexcitability and excess spiking in the cortex. Recent data indicate that E-I ratio increases in multiple mouse models of autism but these changes act to stabilize synaptic depolarization and spiking and thus appear to represent endogenous circuit homeostasis. E-I changes may therefore be an endogenous compensatory response to circuit perturbation, rather than directly driving circuit dysfunction in autism.

Thursday, January 16 at 4:00pm to 5:00pm


Weill Auditorium
1300 York Ave New York, NY 10065

Event Type

Lecture/Seminar

Departments

Brain and Mind Research Institute

Mission

Research

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Brain

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Event Type

Lecture/Seminar

Departments

Brain and Mind Research Institute

Mission

Research

Photo Alt Text

Brain

Subscribe
Google Calendar iCal Outlook

People Interested (1)

Arsalan Haghdel

Getting Here

Detailed Directions

BY CAR

Approaching from south of East 68th Street – Take the FDR Drive northbound to the 61st Street exit. Make right onto York Avenue and go north to 68th Street.

Approaching from north of East 68th Street – Take the FDR Drive southbound to the 71st Street exit. Make left onto York Avenue and go south to 68th Street.

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Take the #6 train to East 68th Street. Walk four blocks east to York Avenue, or take the M66 bus eastbound to York Avenue.

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Take the M31 to the East 69th Street stop, directly in front of Weill Cornell Medical College. (The M31 operates north and south on York Avenue, and across town on 57th Street.)

Crosstown buses M30, M66, and M72 allow you to transfer to the M31 at York Avenue.

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