Kristen E. Pleil, Ph.D.
Assistant Professor of Pharmacology, Weill Cornell Medicine
My lab focuses on delineating the neural circuit mechanisms of addiction and comorbid neuropsychiatric disorders. Given the particularly high degree of coexpression between anxiety/mood disorders and addiction in women but the lack of fundamental knowledge about the underpinnings of these neuropsychiatric diseases in both sexes, we are especially focused on examining the sex-dependent organization and function of the neural circuits that regulate both stress responsivity and drug/alcohol consumption. Further, we are characterizing the plasticity that occurs in these overlapping synaptic nodes with repeated exposure to stressors that drives the expression of these behaviors to accelerate the development of disease states. Here, I will describe how a key neuropeptidergic circuit in the limbic system functions differently in male and female mice and how alterations in estrogen modulation of neuronal excitability and synaptic transmission in this circuit may be a driving factor for the development of multiple neuropsychiatric disease phenotypes.
Thursday, March 15 at 4:00pm to 5:00pm
Weill Cornell Medical College, Weill Auditorium, C-200
1300 York Avenue, New York NY