Kathleen J. Millen, Ph.D.
Professor of Pediatrics University of Washington Seattle, WA
Associate Director, Center for Integrative Brain Research, Seattle Children’s Research Institute
Developmental disruptions of the cerebellum are a significant cause of human neurodevelopmental disorders, including Autism and Medulloblastoma. Mouse studies have been valuable to understand their pathogenesis. However, our recent large-scale genetic analysis of human cerebellar structural birth defects indicates multiple limitations of this model organism. I will present data from our ongoing morphological and molecular studies of normal and pathological human cerebellar development. I will specifically highlight our findings of significant temporal and spatial expansion of human cerebellar progenitor zones relative to other species. These have resulted in complete revisions of our previously mouse-centric models of human cerebellar developmental pathology.
Thursday, December 6 at 4:00pm to 5:00pm
1300 York Ave New York, NY